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Sodium Orthovanadate (CAS Number 13721-39-6, Na3VO4) is a general inhibitor for protein phosphotyrosyl phosphatases (PTPs). Inhibition of vanadate is competitive and can be reversed by addition of EDTA or by dilution. Vanadate is commonly used to preserve the protein tyrosyl phosphorylation state in cells and lysates. BioAssay Systems' Vanadate reagent is activated for maximum inhibition. Suggested Working Concentration: 1-10 mM This product is for Research Use only and is not intended for diagnostic purposes.
In der Herzinsuffizienz führt die chronische Erhöhung des Sympathikotonus zur Desensitivierung des ?-adrenergen Signalweges wodurch nachfolgend die Phosphorylierung von regulatorischen Phosphoproteinen verändert wird. Der Phosphorylierungszustand wichtiger Phosphoproteine kann über eine Aktivierung der entsprechenden Kinase oder eine Hemmung der entsprechenden Phosphatase verändert werden. Die Proteinphosphatasen werden unter anderem durch inhibitorische Proteine reguliert. Der Protein-Phosphatase-Inhibitor-1 stellt eines dieser Proteine dar. Seine potentielle Bedeutung bei der menschlichen Herzinsuffizienz war unklar. Diese Arbeit zeigt erstmalig, dass Inhibitor-1 in der menschlichen Herzinsuffizienz reguliert ist und impliziert, dass die stark verminderte Proteinmenge und Phosphorylierung von Inhibitor-1 als Verstärkerelement der ?-adrenergen Signalkaskade zum Wirkungsverlust von Katecholaminen bei der Herzinsuffizienz beitragen könnten. Die hier dargestellten Befunde implizieren ferner, dass Calcineurin Inhibitor-1 in vivo dephosphorylieren kann. Über Calcineurin könnte Inhibitor-1 einen potentiell wichtigen cross talk zwischen cAMP- und Ca2+-Signalwege im Herzen vermitteln.
Wheat germ acid phosphatase (WGAP) is an enzyme which hydrolyzes para-nitrophenylphosphate (p-NPP) to para-nitrophenol (p-NP). The function of the enzyme was evaluated over a pH range of 3 to 8, with the optimal pH being 5.0. Ammonium molybdate (VI) tetrahydrate, hereafter called molybdate, is an inhibitor which binds to the enzyme or the enzyme-substrate complex.
Recognizes human PPP1R2P9.
Supplied as a liquid in PBS, pH
Purified by Protein A affinity
Functions as a protein phosphatase inhibitor. It inhibits activity of the catalytic subunit of PP1 and weakly inhibits the activity of myosin-associated phosphates. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MSASTSSHRPIKGILKNKSSSGSSVATSGQQSGGTIQDVKRKKSQKWDESSILAAHRATYRDYDLMKANEPGTSYMSVQDNGEDSVRDVEGEDSVRGVEGKEATDASDHSCEVDEQESSEAYMRKILLHKQEKKRQFEMRRRLHYNEELNIKLARQLMWKELQSEDNENEETPQGTNEEKTAAEESEEAPLTGGLQTQSCDP Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
This volume provides a compilation of recent methods for studying protein phosphorylation.
Description : LEVAMISOLE SOLUTION
Supplier No : SP-5000
Levamisole Solution (Alkaline Phosphatase Inhibitor)^
1 set (5 x 1 mL)
Important - Due to the nature of this product, all orders must be shipped to verifiable businesses at commercial addresses. -1SET A cocktail of five phosphatase inhibitors for the inhibition of acid and alkaline phosphatases as well as protein tyrosine phosphatases (PTPs) Suitable for use with cell lysates and tissue extracts, including samples containing detergents.
Our Phosphatase Inhibitor Cocktail-II is a mixture of five phosphatase inhibitors: Imidazole, Sodium Fluoride, Sodium Molybdate, Sodium Orthovanadate, and Sodium Tartrate Dihydrate. This cocktail inhibits the activity of acid phosphatase, alkaline phosphatase and protein tyrosine phosphatases (PTPs) and is suitable for cell and tissue lysates in a lysis buffer with or without detergents.
Wood Boiler Water Treatment
One Gallon treats up to 300 gallons
PacifiClear Defoamer Foam Inhibitor
Formulated specifically for eliminating foaming in pool and spa water without altering the water chemistry or imposing adverse effects on the water or swimmers. Designed to rapidly disperse throughout the water to promptly eliminate existing foam. Remains as a residual to prevent subsequent foam formation for an extended period of time. Acts as both a defoamer and antifoam.
CorQuest 1200 Corrosion & Scale Inhibitor 1/2 Gallon
Prevents metal corrosion, scale, and rust build-up
Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of signaling networks that underlie the cellular workings of human physiology. Initially passed-off as housekeeping genes; these proteins were only acknowledged to maintain a steady background of phosphotyrosine levels in the cell. However, recent progress in studying their role in embryonic development and human disease has established their importance as regulators of signal regulation. Convincing evidence shows the role of mutations in these proteins to cause and/or intensify the severity of various diseases including metabolic and neurological disorders and also cancer. Protein tyrosine phosphatases have slowly, yet convincingly become crucial targets for therapeutic intervention of various human pathophysiologies.This book describes these signaling enzymes using the molecular details of their structure and mechanistic function. Various subtypes of cysteine-based Class I, II, III and the Haloacid dehalogenase related Class IV protein tyrosine phosphatases have been illustrated and explained. The superfamily of proteins is also described vis-a-vis its complimentary protein phosphoserine/phosphoserine phosphatases. Membrane bound receptor forms and the cytosolic non-receptor protein tyrosine phosphatases have been described for their biological function. This book serves as a reference for any reader looking to understand the sequence features, structural elements, molecular mechanism and cellular function of this superfamily of signaling enzymes.
Protein Tyrosine Phosphatases - eBook
Although phosphorylation of proteins on tyrosine is relatively rare compared to phosphorylation on serine or threonine residues, the past two decades of research into PTP function have led to a great appreciation of the critical role PTPs have in regulating basic cellular processes. Among these important roles is the regulation of cellular signaling pathways related to metabolism. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism. Given the growing obesity and diabetes epidemics in the United States and throughout the world, the desire to identify possible therapeutic targets for treatment of these diseases is a high priority. In many ways, PTPs may be attractive drug targets since they are amenable to targeting with small molecules; however many challenges abound in making PTP inhibitors.
Protein Tyrosine Phosphatase Control of Metabolism - eBook
Phosphatases, such as TNAP are fundamental in regulating the roles of cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity. Regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer's disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. This book aims to provide an overview of our current understanding of the functions of TNAP in the brain and on other tissues and organs.
Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP) - eBook
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